Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model

نویسندگان

  • Behzad Khademi Residence of Ophthalmology, Department of ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mahsa Khanlari Pathologist, Department of Pathology, Dr Daneshbod Laboratory, Shiraz, Iran
  • Mina Bamdad Master of Science in developmental Biology, Department of Developmental Biology, Islamic Azad University, Fars, Iran
  • Shahram Bamdad Assistand Professor of ophthalmology, Department of ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran
  • Yahya Daneshbod Pathologist, Department of Pathology, Dr Daneshbod Laboratory, Shiraz, Iran
چکیده مقاله:

Abstract: Title: Teratogenic Effects of Intravitreal Injection of Bevacizumab in Pregnant Rat Models Aim: To investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model Methods: Twenty seven female Wistar rat were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups divided according to the day of intravitreal injections (day 2, 10 and 18). Rats in the case groups received 4 µl intravitreal injection of bevacizumab and the control groups received same volume of distilled water. Results: The tail and umbilical cord length in case groups 1, 2 and 3 did not display any significant differences compared with their control groups. The fetal weight was significantly lower in the case groups 1 (p

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عنوان ژورنال

دوره 16  شماره 2

صفحات  670- 676

تاریخ انتشار 2017-06-01

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